Geno toxicity assays

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Geno toxicity assays(5 marks only)




 Gene-Tox Assays:
  • Assays meet ICH S2(R1) recommendations
  • Assays require a small amount of compound
  • Rapid turnaround time (10 business days)
  • Detect both frameshifts and base-pair substitutions
    • The Ames fluctuation test utilizes 4 Salmonella typhimurium tester strains (TA98, TA100, TA1535 and TA1537)
    • Testing can be performed with and without metabolic activation by rat liver S9 fraction
  • Confirm the negative Ames test results
    • Bacterial cytotoxicity assays are conducted concurrently with Ames test
  • Objective and consistent data
    • The in vitro micronucleus assay uses automated scoring by High Content Analysis (HCA) versus manual scoring.

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